Effective Topical Delivery of Radiomitigator GS-Nitroxide (JP4-039) by Microneedle Arrays
نویسندگان
چکیده
منابع مشابه
Intraesophageal administration of GS-nitroxide (JP4-039) protects against ionizing irradiation-induced esophagitis.
BACKGROUND/AIM this study evaluated esophageal radioprotection by the Gramicidin S (GS) derived-nitroxide, JP4-039, a mitochondrial targeting peptide-isostere covalently-linked to 4-amino-Tempo, delivered in a novel swallowed oil-based (F15) formulation. MATERIALS AND METHODS C57BL/6HNsd female mice received intraesophageal F15 formulation containing JP4-039 (4 mg/ml in 100 microl volumes) 10...
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It was unknown if a mitochondria-targeted nitroxide (JP4-039) could augment potentially lethal damage repair (PLDR) of cells in quiescence. We evaluated 32D cl 3 murine hematopoietic progenitor cells which were irradiated and then either centrifuged to pellets (to simulate PLDR conditions) or left in exponential growth for 0, 24, 48 or 72 h. Pelleted cells demonstrated cell cycle arrest with a ...
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ژورنال
عنوان ژورنال: International Journal of Radiation Oncology*Biology*Physics
سال: 2015
ISSN: 0360-3016
DOI: 10.1016/j.ijrobp.2015.07.1934